Amicus Therapeutics is an international biotechnology company that offers therapies for the orphan and rare diseases. It is a public biopharmaceutical based in Cranbury, New Jersey. Amicus Therapeutics became a public corporation in 2007 under the NASDAQ trading symbol FOLD. Before going public, the company received funding from New Enterprise Associates, Canaan Partners, and Radius Ventures. The biotech’s therapeutic focus is on the lysosomal storage disorders which are the rare and orphan diseases (https://www.indeed.com/q-Amicus-Therapeutics-l-Cranbury,-NJ-jobs.html). Other than its single site located in New Jersey, the company also has another research site in San Diego. The CEO of the corporation is John Crowley who has served in this position since 2005.
In 2010, Amicus Therapeutics partnered with JCR Pharmaceutical to carry out a study on co-formulation with recombinant alpha-galactosidase. Currently, the company is leveraging its biologics as well as CHART to advance the ERT products for Pompe disease, Lysosomal Storage Disorders and Fabry disease. Amicus Therapeutics’ top biologics program is the ATDB200/AT2221 which is a Pompe disease ERT that is set to be administered together with the pharmacological chaperone. The product development cycle of Amicus is based mainly on CHART i.e. Chaperone-Advanced Replacement Therapy. It also focuses more on the advancement of enzyme replacement therapies, ERTs.
By February 2014, Amicus had not launched any marketed products. Up to date, Amicus Therapeutics does not manufacture its products but rather relies on outsourced contracts. Its lead product candidate is migalastat, also known as Galafold. It is a pharmacological chaperone treatment which works as a personalized medicine in late stage development to treat Fabry illness based on genetics diagnosis. This medicine works by stabilizing endogenous mutant alpha-galactosidase. Three years ago, Amicus Therapeutics was recognized for its broad portfolio of small molecule pharmacological chaperones.
Before Crowley took up the role of CEO in Amicus, the company was led by Donald Hayden as the Chairman (Twitter). He continued to serve the company as the Lead Independent Director as Crowley took up the CEO role. The chief scientific officer of the Amicus Therapeutics is David Lockhart, and the chief financial officer is William D. Baird. The executive team also comprises of Brandon Wustman who is the Director of Exploratory Biology and COO, Bradley L. Campell.
In the latest report last Jun 29, 2017, by Matthew CiRullo, the D.O. at Lake Norman Regional Medical Center Arthritis, experts state that osteoarthritis is still a continuous and unceasing cause of worry for many people today in the United States but is not a single disease that doctors can quickly treat. It is long-term and dealing with the pain it causes can be difficult, costly and painful.
With more than 50 million people in the United States dealing with the issues of the 100 types of arthritis, it is a condition that needs complete attention by experts.
The success of the management of the symptoms is dependent on how the patients exercise and take care of their lifestyle and daily routine. Osteo Relief Institute is one of the many groups that promote these management methods.
What Causes Arthritis
One of the many common causes of arthritis is a degenerative joint disease (Facebook). Doctors characterize the condition by the degeneration of the cartilage, which is the soft tissue found between the different joints. The doctors at Osteo Relief may still not have found the cure for arthritis yet, but with the treatments available today, it is easy to find relief for the ailment.
What Is Osteo Relief?
One of the many groups of experts who focus all their attention on making sure the professionals address arthritis is the Osteo Relief Institute. It is the institute that puts all its energy in dealing with the fact that arthritis right now is the important leading cause of disability in the country.
With Osteo Relief Institute’s guide, doctors can now minimize the impact of the condition and manage the risk factors of osteoarthritis, such as excess weight, family history, age and previous injury. Doctors can now also make sure that patients can deal with self-management with greater ease.
Osteo Relief Institute is the institute that helps people with problems with their grinding knees or locking or catching knees, including pain that people feel when they use the stairs and any other knee and leg problems that go with osteoarthritis.
The primary goal of the institute is to make sure that the quality of life of people is improved and maintained. There are many branches of Osteo Relief spread across the country. The one in San Diego is at 1764 San Diego Ave Ste 100, San Diego, CA 92110.
“Hand me that bottle of beer,” so I would tell my wife after a long day at work. As I sit down on the sofa and guzzle down my drink, I feel relieved with the sweet scent and taste of my liquor. However, there is no nice beer like the one that is drunk in the presence of friends, especially the Canadian Craft Beer. Eli Gershkovitch has taken the ‘liquor store model’ to a whole new level. Using brews perfected in Gastown, Eli Gershkovitch has come up with the perfect ales, pilsners, and lagers that make Canadian revelers mouths’ water.
As the CEO of the Steamworks Brewing Company, Eli Gershkovitch has once again placed Canada on the global cartogram, helping a significant percentage of the Canadian Craft Beers scoop numerous awards in the just concluded Open Beer Championship. Some of the best Canadian Craft Beer brands in the market today include the Unibroue 17 Grande Reserve, Fat Tug IPA, Trois Pistoles, Peche Mortel En Fut De, Peche Mortel, and Nectarous.
To be the man he is today, Eli Gershkovitch has had to sacrifice a lot of time and energy to do what he loves best. Working as a pilot and lawyer but on a part time basis, Eli Gershkovitch has been able to create a balance between three distinct careers with being a master brewer dominating among the three. Currently, Steamworks Craft Breweries commands a huge following primarily because Canadians consider it the center of quality and value (CalgaryHerald). By using technology to his advantage, Eli Gershkovitch has been able to diversify and tap into markets that were once non-existent.
At the moment, Eli Gershkovitch is prospecting taking the business to the rest of the world, with the United States of America being his first pits stop. In a nutshell, Eli Gershkovitch has pioneered a new age whereby Canadian Craft Beer is now viewed by the rest of the world as the new black, something that was more of a fallacy a decade ago. It is without saying that out of the more than a hundred Canadian Craft Beers in production today, more than half of the batch beats beers from other parts of the world hands down.
There was a time when Key Performance Indicator or KPI for short, for the shipping industry was measured according to their on time performance. Each type of transportation had its own criteria. For rail movement, it was measured according to schedule departures, ship and aircraft movement was measured by their on time performance and the trucking industry was measured by the service type. Each type was seen as a separate entity when talking about KPI. Not so anymore. With the progress that has been made in all things internet, it is now possible to see it as one unit or entity.
With all this new technology, it is technically possible to track a package from the time the sender takes it to the shipment office, to the point at which it is delivered to the recipient. The problem now industry observers are facing is that they are not getting all the pertinent data to make an informed analysis when deciding KPI. This is because, when a shipment involves most if not all of the different types of shipping, some of the data is either getting lost or is just not available (LinkedIn). For those of you who are trying to make a decision based on performance, this can be a problem. Data such as the cost of shipping, customs clearing, final mile delivery arrangements, Minimum Quantity Commitment (MQC) are now in jeopardy.
However, there is a method to tackle these problems and it is called Electronic Data Interchange or EDI. A company such as Edisoft specializes in this by offering several different products. Started in the mid-1990’s Edisoft spent considerable resources in solving the KPI conundrum. They got the best heads in the business and worked on a software that seamlessly integrates EDI with accounting as well as Enterprise Resource Planning (ERP) software. This allows businesses to take care of their shipping issues with their partners. The company offers several different end-to-end supply chain products such as Edisoft Merchant, MerchantXChange and Merchant QuickPAK. Edisoft Merchant is an integrated EDI platform, MerchantXChange is a Value Added Network and Merchant QuickPAK automates order promotion.
More about Edisoft on https://www.crunchbase.com/organization/edisoft
When looking to start a new business for the very first time, young entrepreneurs often feel challenged at the thought of having to begin with little experience. Glen Wakeman, CEO, and Co-founder of LaunchPad Holdings serves as a stepping stone for self-starters to get their businesses up and running.
Wakeman has been praised for assisting start up businesses and contributing to their development. One of the most accessible ways to find out about different techniques to use as a beginner entrepreneur is through his blogs (Ideamensch). There, he discusses a variety of topics such as business transformation, leadership, emerging markets, etc. But by far the most successful feat accomplished by Wakeman has been his co-owned company, LaunchPad Holdings.
According to Wakeman, the idea of starting a business to help others came from turning ideas into money. From this, LaunchPad Holdings arose. Founded in 2015, their main mission statement is to create a clear path for entrepreneurs to follow, in order to increase their success rates.
Due to Glen Wakeman’s many successes, paying attention to some of his personal insight on different matters can prove to be very valuable as well. One of the most interesting responses from Wakeman came when asked: “What is the best 100 Dollars you have ever spent?” What did he respond? Well, it was investing in a Spanish language course. Learning a new language allowed him to open his mind towards new cultures and the many differences in the world. Not only has he said it, but most importantly he has lived it. Glen Wakeman has resided in six different countries and operates in 30 different regions worldwide. Being able to adapt to the different cultures of the world is an ever-growing importance in the changing global economy of today.
Whether it be his many successes such as his very own company LaunchPad Holdings or simply his words of wisdom, Glen Wakeman has proven to be truly a modern and revolutionary man when it comes to helping early-stage entrepreneurs.
United Technologies continues to invest in people who are creative and intelligent. Without them, we would not have an improved future. For example, The Pratt and Whitney Geared Turbofan engine has gotten an investment of over $10 billion dollars that improves the jet engine. They have calculated and tested the engine to change by improving its fuel burn by 16%, emissions by 50% and noise footprint by 75%! This has changed the air we breathe. There are 14 airlines and 72 aircraft that have used this solution. The better our air crafts are becoming the better our tomorrow has become because of reduced carbon footprint. With that said, travelers can easily go around the world without a worry. Also, with the advances in our technologies, we are able to give out more jobs and opportunities for people who need them. In addition, companies which supply large products for these engines are also gaining profit for gain and advancement. These competitive fields for business have evolved people and the future.
The former chairman and CEO of UTC, Louis R. Chenevert, is a hard working person with an honorable background in his career. He has led his team to the top for the Pratt and Whitney engine. He has helped his team of talented aerospace engineers by placing them where their skills are needed in the commercial and military markets. He lowered the lay offs of the employees which make his team a happy place.
Louis R. Chenevert graduated from Université de Montréal, École des hautes études commerciales (HEC). This university is located in Canada and is a great school for students who want to look into the world’s leading research university. With the excellent research, he has been given the background to lead a team into a great future of improvements. Louis has great leadership skills and wants to change the future of people everywhere. Overall, there are always changes being made in the science of technology to better our world from disease or pollution. A great team of people is only the beginning of the future.
One thing that entrepreneurs need when they are working towards their goals is assistance. This is where Glen Wakeman comes in. Glen Wakeman is an entrepreneur and an investor. He particularly offers help to entrepreneurs who are starting out. He is especially willing to share his insights about the markets so that other entrepreneurs who are hoping to make a fortune are able to profit from his knowledge. Glen Wakeman has a lot of insight that comes from his observation of the markets. For one thing, he has taken a look at every aspect of the market in order to find emerging markets and other opportunities for people.
As well as an investor, Glen Wakeman is also a writer. Therefore, he can articulate everything he has learned about the markets and industry he is in so that others can learn from his example and make the right choices. One of the best ways that writers can work on their craft and get noticed is through blogging. Glen Wakeman himself uses blog posts in order to share information that will help people learn a bunch of different lessons that will help them in their path to success in the financial investment markets.
Other things that Glen Wakeman writes about on his blog are global affairs, business transformation, leadership, and plenty of other things that can have an effect on the market (Facebook). One thing that Glen Wakeman shows is that he is aware of the world around him. This is one thing that is needed for people to be able to weather any types of storms that may come towards them. When one has an awareness of everything that could affect his business, then he could adequately prepare for what may come so that his business will still be there after the worst is over.
As a new political action team in America, End Citizens United has been striving to remain relevant in the political landscape. The company is dedicated to conducting fair elections through its platform. End Citizens United has been the talk of politics given its persistence in pursuing political reforms. The group is committed to developing campaign changes geared towards fair elections. End Citizens United launched its operations by after raising $ 2 million. This amount was generated from small donors who are committed to the promoting the good cause of the group.
The main goal of End Citizens United is to participate in the constitutional amendment of passing a law that reverses the decision of the Supreme Court. Towards this end, over 325,000 individuals have been involved in the signing of the petition. This petition demands congress to pass legislation. According to End Citizens United, the number is likely to increase because the organization has partnered with Hillary Clinton. End Citizens United is proud to announce the endorsement of approximately 11 democrats. This number includes Senator Russ Feingold as well as Senator Michael Bennet.
End Citizens United has been focused on raising money to facilitate the elections. The organization has raised more than $4 million. With a focus to remain relevant during the next elections, End Citizens United has the objective of raising $ 35 million come mid-2018. Considering the amount the political action committee spent in the 2016 elections, this goal is realistic. According to Muller of End Citizens United, the team has attracted more than 100,000 new members. More than 30,000 people have made their first contribution. The group commits to chairing finance reforms towards congress elections. With the new cabinet in place, End Citizens United feels that Trump and his cabinet have demeaned them. With that in mind, the team is committed to transforming the political landscape by winning the 2018 congress elections.
End Citizens United is focused on fighting back. This is because of a few weeks ago, the team mobilized contributors with the aim of receiving donations for elections. One candidate from the team surprised everyone when he parted with more than $ 4 million. Mr. Jon Ossoff of Georgia is a first-time political candidate. He will be vying for Tom Price’s position. Tom was elected to health services position. In a different scenario, Muller was a political director for the Senate Democrats. She will be in charge of examining the campaign in 2018. Muller will ensure that the elections are conducted fairly.
End Citizens United is a political action committee. The organization has been chairing reforms in the American political landscape. Since its establishment in 2015, End Citizens United has been in the lead in conducting finance reforms.
Bumble is an online dating app that has been expanding since it was launched by Whitney Wolfe. Ms. Whitney through the app has been redrafting the rules of online dating. Asked what inspired her to design the app; she mentioned her purpose was to assist women who are seeking long term relationships through online dating and to ensure that the process is not annoying, discouraging, demeaning or even off-putting like most online dating apps.
According to a study carried out by Fast Company in 2013; 23% of women who used online dating apps felt uncomfortable and some of them were harassed, while only 17% of men had the same experience.
Whitney Wolfe felt the urge and was very passionate to assist online dating women by stopping the harassment. After being mentorship and advice from her friend and business partner Andrew Andreev; Whitney Wolfe went ahead to found Bumble which is well described as an Austin-based dating app. With bumble app, both women and men express their liking by tapping into each other’s profiles and only the woman has the ability to make the first contact after liking each other and now they can agree on how to meet. The app has been expanding marvelous and by 2016 it recorded more than 7 million users and 25 billion profile views. In the near future, the founders of the app are planning to expand its services to new levels of “Bumble BFF” that will go by the name Bumble Bizz. The main aim of Bumble BFF is for individuals to find both platonic and professional friends and connections.
Whitney Wolfe is the founder and the Chief Executive Officer of Bumble dating app. Ms. Wolfe was also the co-founder of another dating app; Tinder. Whitney was born and grew in Salt Lake City, Utah. Whitney Wolfe’s father was a property developer while her mother was a house wife. After her graduation from High School Whitney attended Southern Methodist University and he studied International studies.
Whitney Wolfe began her career at a young age of 22 when she serves at Hatch Labs where she participated in a start-up cardify a project that was led by Sean Rad. Wolfe has been passionate about women dating life especially online and after Tinder, she founded Bumble which is known to feminine. Together with her partner they are devoted to change the lives of women using dating apps.